sprouty regulation of tyrosine kinase signals
| PAG Title | sprouty regulation of tyrosine kinase signals |
| PAG ID | WAG000211 |
| Type | P |
| Source Link |  BioCarta |
| Publication Reference | NA |
| PAG Description | Four different members of the Sprouty protein family block the cellular proliferation and differentiation induced by several different growth factors, including EGF and FGF. One mechanism by which Sprouty proteins inhibit sigling is through binding to Grb-2, a sigling intermediary between the tyrosine kise growth factors and the Ras/map kise pathway. Binding of Sprouty to Grb-2 prevents Grb-2 and Sos-1 from interacting with downstream sigling factors that activate Ras and map kises, including Ras, Raf-1, Mek1, Erk1/2 and downstream transcription factors. The action of Sprouty as an inhibitor of this pathway requires Sprouty phosphorylation and membrane localization, at the site of the factors it interacts with. The inhibition of growth factor sigling by Sprouty is specific to the Ras pathway since the PI3 Kise pathway responsible for cell survival sigls from growth factor receptors is not inhibited by Sprouty. Tyrosine kise activity of growth factor receptors is also not affected. The mechanism by which Sprouty inhibits Ras activation may be by blocking the nucleotide exchange activity of Sos. Sprouty expression is induced by growth factor receptor activation of Ras sigling, provided a self-regulatory feedback inhibition mechanism that regulates growth factor sigling through Ras. |
| Species | Homo sapiens |
| nCoCo Score | 4,010 |
| Base PAG ID | WAG000211 |
| Human Phenotyte Annotation | |
| Curator | PAGER curation team |
| Curator Contact | PAGER-contact@googlegroups.com |
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